Oh I agree with you that the microbiome is the key to figuring out autoimmune diseases. I take a prescription based probiotic twice a week that is not covered by insurance and is ridiculously expensive. But whenever I miss too many doses...the wheels come off this old bus.
I am constantly asking my GI - "When will we have mapped the microbiome." He also tells me we are at least 10 years off. But once we do, it will be a game changer.
As for my altered immune system, I suspect pregnancy changed my microbiome and then stress lit the fire. But I am just spit balling.